Man Utd and Erik ten Hag are desperate for a win this weekend as the Premier League returns following the international break.
The Red Devils take on one of the newly promoted sides, Southampton, who have lost every league game in 2024/25 so far.
Match Preview
Southampton Recent Form
Southampton have lost all three of their Premier League matches since earning promotion back into the top flight. They lost 1-0 against Newcastle on the opening day and followed that with defeats at home against Nottingham Forest and away at Brentford.
They have found the back of the net on just one occasion so far, and conceded five.
The Saints earned a short reprieve in the League Cup as they won 5-3 away at Cardiff.
Southampton Injury News
Gavin Bazunu remains out and won't play until 2025 at the earliest.
Kamaldeen and Sulemana and Ross Stewart are nearing return from injury, but Saturday will come to quickly for them to feature from the start.
Last Southampton Lineup
Southampton (3-5-2): Ramsdale; Hardwood-Bells, Bednarek, Stephens; Sugawara, Smallbone, Downes, Aribo, Walker-Peters; Armstrong, Brereton Diaz
Man Utd Recent Form
United weren't at their best on the opening day but still managed to claim all three points against Fulham thanks to a late goal from new signing Joshua Zirkzee.
They then lost 2-1 in the last minute against Brighton before being humbled 3-0 at home by arch-rivals, Liverpool. Ten Hag is under pressure already and we are only three games into the new campaign.
Man Utd Injury News
Leny Yoro, Tyrell Malacia, Mason Mount, Rasmus Hojlund, Victor Lindelöf and Luke Shaw are on the treatment table for United, but there is hope that Shaw and Lindelöf could return soon.
Bruno Fernandes suffered a knock while on international duty with Portugal, but he'll be fine to start at St. Mary's.
Last Man Utd Lineup
Man Utd (4-2-3-1): Onana, Mazraoui, De Ligt, Martinez, Dalot; Casemiro, Mainoo; Garnacho, Fernandes, Rashford; Zirkzee
Southampton vs Man Utd - who is the referee and VAR?
Referee: Stuart Attwell
Assistants: Constantine Hatzidakis, Nick Hopton
Fourth official: Gavin Ward
VAR: Chris Kavanagh
Assistant VAR: Lee Betts
Southampton - Player To Watch
Yukinari Sagawara has been a bright spark in an otherwise fairly downbeat start to the season for Southampton, and he remains their only player to have scored in the league this season. He looks an inspired piece of transfer business.
Man Utd - Player To Watch
Fernandes is yet to really get going for Man Utd so far this campaign but did open his goalscoring account for the new season with a goal for Portugal against Scotland, so maybe that will act as the catalyst for him to get back to near his best for the Red Devils.
Southampton vs Man Utd - Prediction
Manchester United to Win and Over 2. Goals Scored
Southampton have lost their last 2 home games, while in four of Man Utd's last six away games there has been over two goals scored.
Scoreline prediction - Southampton 1-3 Man Utd
Man Utd vs Southampton - Betting Tips
Man Utd to Win and Both Teams to Score
Southampton have scored in four and conceded in five of their last six home games, while United have scored in five and conceded in six of their last six away games.
Both Teams to Score
Southampton have scored in 4 and conceded in 5 of their last 6 home games, while Manchester United have scored in 5 and conceded in 5 of their last 6 away games.